🔬 University of Barcelona · Peer-Reviewed Research
In the Seville region of southern Spain, botanists had long known that bitter orange peel possessed unusual metabolic properties. Women in the region who consumed it regularly appeared to maintain leaner physiques despite similar diets to their peers.
When researchers finally isolated the active compound — p-synephrine — the results were remarkable. Unlike caffeine or ephedra, which raise heart rate and blood pressure to create thermogenesis, p-synephrine acts on a completely different pathway: the beta-3 adrenergic receptors in fat cells.
The key finding: p-Synephrine triggered a 74% increase in thermogenesis in clinical subjects — without raising heart rate, blood pressure, or causing any stimulant-related side effects. Women over 40 with compromised cardiovascular sensitivity could use it safely.
But p-synephrine alone addresses only one part of the thermogenic system. The full reset requires targeting 6 additional metabolic levers — which is exactly what CitrusBurn's formula does.
